Our Science
Developing a Natural Solution for Weight Management
ZAP-100 is a plant-derived, non-stimulant supplement that targets the brain’s hunger regulating neurons to help restore energy balance, without crash diets or harsh pharmaceuticals.
Your Brain Controls Hunger and Energy
The hypothalamus is a small but powerful region of the brain that regulates appetite and energy use. It does this through two types of neurons:
NPY/AgRP neurons, which stimulate appetite
POMC neurons, which suppress appetite
These neurons sense circulating hormones like insulin and leptin, as well as nutrients like sugar and fat. They continuously adjust your hunger and energy expenditure in response to what your body needs. When this balance is disrupted, long-term weight gain can occur.
Modern Life Disrupts the Brain’s Appetite Signals
Multiple factors in our environment can impair the brain’s ability to regulate hunger and metabolism. These include:
Frequent consumption of high-fat, high-sugar foods
Insulin resistance and metabolic dysfunction
Exposure to endocrine-disrupting chemicals like BPA
Irregular sleep cycles and shift work
Over time, these stressors interfere with the hypothalamus, leading to increased appetite, decreased energy expenditure, and progressive weight gain.
Most importantly, if you have struggled with achieving your weight goals…
You Are Not Alone.
Over 2.5B Adults Are Overweight; 890M Are Obese
90% of Existing Weight Loss Products Fail
ZAP-100 Rebalances the Brain’s Hunger Signals
ZAP-100 is a naturally derived plant hormone that restores appetite control by acting directly on the hypothalamus. In preclinical studies, it:
Decreased expression of NPY, the brain’s most potent appetite stimulant
Increased expression of POMC, which promotes satiety and thermogenesis
This dual action reduces food intake and boosts energy expenditure, leading to sustainable weight loss even in animals fed a high-fat diet.
A New Standard for Natural Appetite Support
Unlike stimulant-based supplements or injectable GLP-1 drugs, ZAP-100 is:
Derived from plants with no added stimulants
Designed to gently modulate brain-based hunger pathways
Intended for use as a capsule or emulsion without injections
Free from adverse side effects and suitable for long-term support
ZAP-100 offers a safe, accessible alternative for people looking to take back control of their appetite, without side effects or lifestyle disruption.
Preclinical Findings
Daily oral feeding of ZAP-100 decreases body weight in obese mice while maintained on a diet high in fat.
Daily oral feeding of ZAP-100 decreases food intake in obese mice while maintained on a diet high in fat.
4 weeks of daily ZAP-100 feeding decreases blood glucose levels in mice during the glucose tolerance test (i.e., have improved glucose homeostasis).
