Our Science
Developing a Natural Solution for Weight Management
Harnessing Evolutionary Biology
ZAP-100 mimics a plant hormone found in nature
Our novel compound, ZAP-100, is synthetically produced to replicate a naturally occurring plant hormone (cytokinin) found in all plants. It has been safely used in agriculture for decades and is now being repurposed for human health.
First-in Class Appetite Regulator
Nature-Identical. Brain-targeted.
ZAP-100 is a plant-identical, non-stimulant supplement that targets the brain’s hunger regulating neurons to help restore energy balance, without crash diets or harsh pharmaceuticals.
Regulating Hunger at the Source
Dual regulation of hunger and satiety neurons
ZAP-100 restores appetite control by acting directly on the hypothalamus, the brain’s appetite center. It reduces activity in hunger-stimulating neurons (NPY) and boosts signals from appetite-suppressing neurons (POMC). This dual action leads to sustainable weight loss, even in animals fed a high-fat diet.
Preclinical Results at a Glance
Preclinical (Animal) studies conducted by Dr. Belsham’s research team at the University of Toronto.
Finding 1: Significant Weight Loss Without Dietary Changes
Obese mice taking ZAP-100 and fed a high-fat diet lost significantly more weight (15% in just 4 weeks), compared to controls.
Finding 2: Appetite Suppression Enables Weight Loss
Obese mice taking ZAP-100 consumed less food (~20%) starting within the first week of treatment, with sustained lower intake throughout the 4-week study.
Finding 3: Improved Blood Glucose Control
After 4 weeks of treatment, obese mice taking ZAP-100 showed significantly better glucose clearance after a glucose challenge, indicating improved blood glucose control.
